Predicting type 2 diabetes and testosterone effects in high-risk Australian men: development and external validation of a 2-year risk model

Eur J Endocrinol. 2025 Jan 6;192(1):15-24. doi: 10.1093/ejendo/lvae166. ABSTRACT OBJECTIVE: We have shown that men aged 50 years+ at high risk of type 2 diabetes treated with testosterone together with a lifestyle program reduced the risk of type 2 diabetes at 2 years by 40% compared to a lifestyle program alone. To develop a personalized … Read more

Why Vitamin K2 is one of the ULTIMATE Hormone Optimization Tools

🔥 ATTENTION MEN: This is NOT Your Average Vitamin Listen up. Most men are SABOTAGING their testosterone without even knowing it. The SECRET WEAPON? Vitamin K2. 🚀 HORMONE DOMINATION: How K2 Transforms Your Masculinity What if I told you there’s a SINGLE NUTRIENT that can: K2 isn’t just a vitamin. It’s your hormonal TACTICAL NUCLEAR … Read more

Age and sex effects of a validated LC-MS/MS method for the simultaneous quantification of testosterone, allopregnanolone, and its isomers in human serum

Sci Rep. 2024 Nov 13;14(1):27777. doi: 10.1038/s41598-024-78807-3. ABSTRACT Despite the great relevance of the neurosteroid allopregnanolone and related isomers to various health conditions, quantification typically involves immunoassay, which suffers from serious issues with cross-reactivity of closely related molecules. This article describes the development and partial validation of a liquid chromatography coupled with tandem mass spectrometry … Read more

Testosterone levels increase following bariatric surgery – validation of preceding literature in a large-scale population analysis

Andrology. 2025 Mar;13(3):431-438. doi: 10.1111/andr.13689. Epub 2024 Jul 3. ABSTRACT BACKGROUND: The effects of bariatric surgery on testosterone levels in men with obesity and hypogonadism have not been thoroughly explored yet. OBJECTIVES: To investigate the possible effects of bariatric surgery on T levels in obese hypogonadal men by comparing T levels before and after surgery … Read more

Intraprostatic hormone dosage: Validation of a novel prostate biopsy technique

Fr J Urol. 2024 Jul;34(7-8):102659. doi: 10.1016/j.fjurol.2024.102659. Epub 2024 May 31. ABSTRACT BACKGROUND: Advances in chromatography and mass spectrometry have allowed us to develop a novel technique for measuring intraprostatic hormone concentrations directly on prostate needle biopsies, rather than using traditional punch excision. This has significant clinical implications as intraprostatic dihydrotestosterone and testosterone levels could … Read more

Carbon isotope ratios of phenethylamine and its urinary metabolite phenylacetylglutamine

Drug Test Anal. 2024 Sep;16(9):977-988. doi: 10.1002/dta.3616. Epub 2023 Dec 4. ABSTRACT Phenethylamine (PEA) is a naturally occurring trace amine that acts as a modulator in the central nervous system. It is widely sold as a dietary supplement and advertised for its mood enhancing effects and should support weight loss. It is prohibited in sports … Read more

Ultraviolet spectra determination and computational analysis of 44 E/Z steroid isomers in dried blood spot

Drug Test Anal. 2024 Jun;16(6):661-673. doi: 10.1002/dta.3598. Epub 2023 Nov 13. ABSTRACT The dried blood spot (DBS) is a novel alternative matrix used in 2022 Beijing Winter Olympics and Paralympics. It is capable of distinguishing anabolic androgenic steroid (AAS) esters without the gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS) confirmation. In this study, a method for … Read more

Validation of circulating steroid hormone measurements across different matrices by liquid chromatography-tandem mass spectrometry

Steroids. 2021 Mar;167:108800. doi: 10.1016/j.steroids.2021.108800. Epub 2021 Feb 5. ABSTRACT BACKGROUND: Steroid hormones are essential signalling molecules in prostate cancer (PC). However, many studies focusing on liquid biomarkers fail to take the hormonal status of these patients into account. Steroid measurements are sensitive to bias caused by matrix effects, thus assessing potential matrix effects is … Read more